I’ve been getting a couple hundred spam comments a day. WP catches 99% of them, if not more, but I still have to dump the trash.
If you are getting tired of shoveling out your spam comments, take a moment to look through them and see what post or page the spammer replied to. Then change the URL (WP calls it the ‘permalink’), even by just a character. Bingo. Their old spammable post or page no longer exists.
The only drag is that this will also break any legit links that other sites have made to your page. At this point, it was worth it.